Model establishment and progress of focused gene therapy for dilated cardiomyopathy
10.3969/j.issn.1005-4847.2023.11.010
- VernacularTitle:聚焦基因治疗的扩张型心肌病模型构建及进展
- Author:
Yulin CHEN
1
;
Hugang JIANG
;
Tao AN
;
Wen LI
;
Chunyan YAN
;
Qian HUANG
;
Kai LIU
;
Yingdong LI
;
Xinke ZHAO
Author Information
1. 甘肃中医药大学 中西医结合学院,兰州 730000
- Keywords:
dilated cardiomyopathy;
LMNA mutation;
gene therapy;
animal model
- From:
Acta Laboratorium Animalis Scientia Sinica
2023;31(11):1462-1469
- CountryChina
- Language:Chinese
-
Abstract:
Dilated cardiomyopathy is a main disease that causes heart failure and exhibits etiological heterogeneity.Nearly a quarter of dilated cardiomyopathy in patients is related to genetics,and ventricular dilation and myocardial systolic dysfunction are the main characteristics of the disease.LMNA mutation is a major cause of hereditary dilated cardiomyopathy,and arrhythmia is a major clinical manifestation of hereditary dilated cardiomyopathy with LMNA mutation.In recent years,establishment of a dilated cardiomyopathy model in C57/B6 mice and its treatment by focused gene therapy has been a research focus,and some important conclusion have been drawn from the establishment of large animal models in dogs and pigs.However,large animals,especially non-human primates,are closer to humans.At present,dilated cardiomyopathy is not involved in the heart disease model of non-human primates.Therefore,this article reviews studies on rodent and large animal models of dilated cardiomyopathy at the genetic level and proposes the idea of developing a dilated cardiomyopathy model in a non-human primate.It also provides new ideas to study the pathogenesis and clinical treatment.
