HIV antiretroviral therapy among blood donors: the impact on blood safety
10.13303/j.cjbt.issn.1004549x.2024.02.003
- VernacularTitle:献血者使用HIV抗病毒治疗药物对血液安全的影响
- Author:
Lilin WANG
1
;
Fang ZHAO
2
;
Zhengrong YANG
3
;
Rui ZHU
1
;
Yizhong LIU
4
;
Linfeng WU
1
;
Tong LI
1
;
Tingting CHEN
1
;
Jinfeng ZENG
1
Author Information
1. Shenzhen Blood Center, Shenzhen 518035, China
2. Shenzhen Third People′s Hospital
3. Shenzhen Center for Disease Control and Prevention
4. Shenzhen Bao′an District Central Blood Bank
- Publication Type:Journal Article
- Keywords:
voluntary blood donors;
antiretroviral therapy(ART) drugs;
HIV;
detection rate;
blood safety
- From:
Chinese Journal of Blood Transfusion
2024;37(2):138-144
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the the potential risks of antiretroviral therapy(ART) drugs on blood safety among blood donors in Shenzhen. 【Methods】 High pressure liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) was used to measure ART drugs concentrations in the plasma of regular blood donors (negative control group, n=86) and anti-HIV positive individuals (experimental group, n=98, detected from approximately 440 000 blood donors during 2019—2023). The baseline plasma concentrations of ART drugs in the negative control group were clarified, and the impact of ART drugs on blood safety was analyzed. 【Results】 The baseline concentrations of ART drugs were not detected in 86 samples of negative control group. Four positive ART drugs samples were detected in 1∶2 pooled plasma samples of 98 anti-HIV positive blood donors plasma in the resolution test. The ART positive rate of anti-HIV positive donors was 4.08%, with tenofovir, lamivudine and efavirenz detected in three blood donors and lamivudine, lopinavir, ritonavir and zidovudine detected in one blood donor. 【Conclusion】 ART drugs were found among anti-HIV positive blood donors in Shenzhen. Additional research is needed to investigate the motivation of these specific donors, so as to ascertain the groups most susceptible to potential risks, and guarantee blood safety.
