Research progress on the influence of ligands on the stability of albumin

VernacularTitle:配体对白蛋白稳定性影响的研究进展
Author: Lieqing YANG ¹ ; Rongchao YIN ¹ ; Lei YANG ¹ ; Jinrong JING ¹ ; Haitao FANG ¹ ; Jiaquan CHEN ¹ ; Weixin LIU ¹
Author Information

1. Shandong Taibang Biological Products Co., Ltd., Taian 271000, China
Publication Type:Journal Article
Keywords: albumin stability; sodium octanoate; N-acetyl-L-tryptophan; N-acetyl-L-methionine
From: Chinese Journal of Blood Transfusion 2024;37(1):120-124
CountryChina
Language:Chinese
Abstract: It is necessary to improve the stability of human serum albumin in response to the complex temperature, light and other conditions during the manufacture and storage. In this paper, the stabilization effect and simple stabilization mechanism of ligands on albumin were described from the perspective of ligand binding to albumin.Through review and comparison, it can be concluded that the common ligand sodium octanoate mainly plays a role in improving thermal stability, and the common ligand N-acetyl-L-tryptophan mainly plays a role in improving antioxidant activity, N-acetyl-L-methionine has better antioxidant and anti-photooxidation than N-acetyl-L-tryptophan.