Allele frequency polymorphism of Duffy, Kidd, Diego blood group system: a study in Dongxiang ethnic group in Gansu Province

Jun Cui; Weiping Zhang; Xia Hui; Xiaoping Zhang; Guoying LI; Haiyan Yang

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Allele frequency polymorphism of Duffy, Kidd, Diego blood group system: a study in Dongxiang ethnic group in Gansu Province

VernacularTitle:东乡族人群Duffy、Kidd、Diego血型系统等位基因频率多态性研究
Author: Jun CUI ¹ ; Weiping ZHANG ² ; Xia HUI ¹ ; Xiaoping ZHANG ³ ; Guoying LI ² ; Haiyan YANG ¹
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1. Linxia Hui Autonomous Prefecture Central Blood Station, Linxia 731100, China
2. Gansu Red Cross Blood Center
3. Gansu Provincial People's Hospital
Publication Type:Journal Article
Keywords: RBC blood group; allele frequency; gene polymorphism; Dongxiang ethnic
From: Chinese Journal of Blood Transfusion 2024;37(1):68-72
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the allele frequencies polymorphic distribution of Duffy, Kidd and Diego blood group systems in Dongxiang ethnic group in Gansu Province. 【Methods】 Blood samples of 100 unrelated blood donors were randomly selected from Dongxiang ethnic group in Gansu from January to December 2017. Allelic typing of Duffy, Kidd and Diego blood groups was performed by fluorescence PCR. 【Results】 The allele frequencies of Duffy, Kidd, and Diego blood group systems of Dongxiang ethnic group were 0.835 for Fy^*01, 0.165 for Fy^*02, 0.570 for Jk^*01, 0.430 for Jk^*02, 0.020 for DI^*01, 0.980 for DI^*02, respectively. No Fy(a-b-), Jk(a-b-), Di(a+b-) rare phenotypes were found. The antigen incompatibility rates of Fy^a/Fy^b, Jk^a/Jk^b, Di^a/Di^b of Duffy, Kidd, and Diego blood group systems were 23.76%, 37.01% and 3.84%, respectively. 【Conclusion】 The allele frequencies distribution of Duffy, Kidd and Diego blood group systems in Dongxiang ethnic group in Gansu were polymorphic and has unique ethnic distribution characteristics.