Research advances in glutamate and γ-aminobutyric acid homeostasis imbalance in major depressive disor-der
10.3969/j.issn.1002-0152.2023.12.010
- VernacularTitle:重性抑郁障碍谷氨酸与γ-氨基丁酸稳态失衡研究进展
- Author:
Mian LI
1
;
Zhonglin TAN
;
Yue WU
;
Sugai LIANG
Author Information
1. 浙江中医药大学第四临床医学院(杭州 310053)
- Keywords:
Major depressive disorder;
Glutamate;
γ-aminobutyric acid;
Homeostasis imbalance;
Magnetic resonance spectroscopy;
Targeted regulation;
Treatment
- From:
Chinese Journal of Nervous and Mental Diseases
2023;49(12):758-764
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal homeostasis of glutamate(Glu)and γ-aminobutyric acid(GABA)in the brain is one of pathophysiological mechanisms of brain dysfunction in major depressive disorder(MDD).Neurotransmitters play an important role in maintaining chemical balance in the brain,and pharmacological and non-pharmacological therapies based on resetting excitation-inhibitory neurotransmitter system rebalancing are of interest.Studies based on magnetic resonance spectroscopy(MRS)have shown a homeostasis imbalance of Glu and GABA in the brain of MDD patients.Pharmacological therapies such as ketamine,selective serotonin reuptake inhibitors,and other novel receptor modulators and non-pharmacological therapies such as repetitive transcranial magnetic stimulation,electroconvulsive therapy,and physical exercise can target on the regulation of neurotransmitter levels.Abnormal homeostasis of Glu and GABA provides theoretical support for revealing pathophysiologic mechanisms of MDD,exploring neurotransmitter biomarkers,guiding clinical practice and facilitating personalized treatment.
