Study on the efficacy and safety of light room therapy as an adjunctive treatment for depression
10.3969/j.issn.1002-0152.2023.12.003
- VernacularTitle:室内光照辅助治疗抑郁症的疗效与安全性研究
- Author:
Ruojia REN
1
;
Wenting LU
;
Yuanyuan GAO
;
Na LI
;
Li YANG
;
Tianyu ZHAO
;
Shijie GUO
;
Fanfan HUANG
;
Bufan LIU
;
Quan LIN
;
Yuehang XU
;
Na JIN
;
Xi YANG
;
Xueyi WANG
Author Information
1. 河北医科大学精神卫生中心,河北省精神心理疾病临床医学研究中心,河北省精神卫生研究所,河北省精神心理健康评估与干预技术创新中心(石家庄 050031)
- Keywords:
Light therapy;
Light room;
Depression;
Adjuvant therapy;
Rapid onset;
Clinical efficacy;
Safety
- From:
Chinese Journal of Nervous and Mental Diseases
2023;49(12):720-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether indoor light-assisted therapy can rapidly improve depression and anxiety symptoms in patients with depression,as well as the safety of indoor-light-assisted therapy.Methods From September 2021 to December 2022,patients with depression were recruited from the Mental Health Center of the First Hospital of Hebei Medical University.According to the random number table method,patients were divided into test group and control group.The test group was treated with light therapy 30 minutes from 7:30 am to 8:00 am daily for 2 weeks in addition to antidepressant therapy.Antidepressant therapy was continued after completion of light therapy and patients were followed up for 2 weeks.The control group was treated with regular antidepressants throughout the four-week trial.Hamilton depression scale(HAMD17)and the Hamilton anxiety scale(HAMA)were used to assess the clinical symptoms at the baseline and the end of every week of treatment.Safety was evaluated using patient adverse events,anterior segment photography and visual testing.Results A total of 80 patients were enrolled,including 40 in the test group and 40 in the control group.The data of dropped were processed for missing values and then included in the statistical analysis.At the 1st(20.0％vs.0.0％)and 2nd(45.0％vs.17.5％)weekend of treatment,the response rate in the test group was significantly higher than that in the control group.There was an interaction between the time point and the group in HAMD17 total score(F=9.66,P<0.01).The scores of HAMD17 at the end of every week in the test group were significantly lower than that in the control group(P<0.05).There were significant differences in the reduction rate of total score in HAMD17[33.3％(25.0％,43.3％)vs.13.9％(9.9％,19.8％)]and HAMA[22.4％(16.5％,35.3％)vs.14.2％(4.4％,26.9％)]between the two groups(P<0.05).Incidences of adverse effect were not significantly different between the two groups(12.5％vs.10.0％,P=1.00).There were no severe adverse events or mania was reported in the test group and the eye examination showed no abnormality.Conclusion Compared with antidepressant therapy alone,indoor light therapy combined with antidepressant can quickly improve depression and anxiety symptoms in patients with depression,shorten the duration of depression treatment,and has good safety.
