The research progress on the impact of bone marrow mesenchymal stem cell-derived extracellular vesicles on traumatic brain injury
10.3969/j.issn.1002-0152.2023.11.011
- VernacularTitle:骨髓间充质干细胞来源外泌体对创伤性颅脑损伤的影响研究进展
- Author:
Haodong LIU
1
,
2
;
Zejun WU
;
Junshuang ZHAO
;
Juntao HU
Author Information
1. 湖北医药学院附属太和医院神经外科(十堰 442000)
2. 湖北医药学院
- Keywords:
Traumatic brain injury;
Neuroinflammation;
Neural regeneration;
Bone marrow mesenchymal stem cells;
Extracellular vesicles;
MicroRNA
- From:
Chinese Journal of Nervous and Mental Diseases
2023;49(11):700-704
- CountryChina
- Language:Chinese
-
Abstract:
Traumatic brain injury(TBI)is a multifaceted disease with a complex pathogenesis for which there are currently no effective therapeutic interventions.Research has shown that bone marrow mesenchymal stem cell-derived extracellular vesicles(BMSC-EVs)may play a therapeutic role in TBI.They attenuate neuroinflammatory responses at the site of the lesion and promote neurovascular regeneration.However,the exact mechanisms underlying their actions are not fully understood.This article aims to review the current state of research on the therapeutic mechanisms of BMSC-EVs in TBI.It also aims to discuss possible future research directions and potential clinical applications of BMSC-EVs.
