Anti-inflammatory immunotherapy in febrile infection-associated epilepsy syndrome
10.3969/j.issn.1002-0152.2023.11.010
- VernacularTitle:抗炎免疫疗法在发热感染相关性癫痫综合征中应用进展
- Author:
Bo WANG
1
;
Huifang DENG
;
Jing SUN
;
Qingpeng WANG
;
Dandan SU
;
Cheng LIANG
Author Information
1. 兰州大学第二医院神经内科ICU(兰州 730030)
- Keywords:
Febrile infection-related epilepsy syndrome;
Refractory status epilepticus;
Anti-inflammatory im-munotherapy;
Anakinra;
Ketogenic diet;
Cannabidiol
- From:
Chinese Journal of Nervous and Mental Diseases
2023;49(11):695-699
- CountryChina
- Language:Chinese
-
Abstract:
Febrile infection-related epilepsy syndrome(FIRES)is a lethal encephalopathy with refractory status epilepticus as the main manifestation,and the selection of effective antiepileptic drugs(AEDs)is the focus and difficulty of treatment.This review summarises the mechanism of action,drug administration and adverse effects of different anti-inflammatory immunotherapies in the treatment of this disease,and finds that early initiation of ketogenic diet(KD)is one of the most effective treatments at present,and further studies are needed to clarify the adverse effects of the drugs and the effects of the combination of different drugs.
