Clinical effectiveness and its mechanisms of deep brain stimulation in treatment-resistant depressive disor-ders
10.3969/j.issn.1002-0152.2023.11.007
- VernacularTitle:脑深部电刺激治疗难治性抑郁障碍临床疗效及机制研究进展
- Author:
Xin LYU
1
;
Kuanghao YE
;
Yuhan WANG
;
Bomin SUN
Author Information
1. 上海交通大学医学院附属瑞金医院功能神经外科(上海 200025)
- Keywords:
Treatment-resistant depressive disorder;
Deep brain stimulation;
Subgenual cingulate gyrus;
Ven-tral capsule/ventral striatum;
Amygdala
- From:
Chinese Journal of Nervous and Mental Diseases
2023;49(11):675-681
- CountryChina
- Language:Chinese
-
Abstract:
Deep brain electrical stimulation is one of the emerging therapeutic approaches for treatment-resistant depressive disorders.This article outlines a variety of potential targets for deep brain electrical stimulation in the treatment of treatment-resistant depressive disorders and summarizes the results of relevant clinical studies.These targets include the subgenual cingulate gyrus,nucleus accumbens,ventral capsule and ventral striatum area,medial forebrain bundle,and lateral habenula,among other regions.Based on these studies,the article integrates relevant basic research and further discusses the possible mechanisms through which deep brain stimulation may exert therapeutic effects,including synaptic plasticity,neurophysiology,neural circuits,and neurotransmitters.The article also assesses and prospects the further application potential of deep brain electrical stimulation.The authors believe that the multi-target stimulation combining existing clinical research results and neurobiological mechanisms could be a crucial development direction to enhance the treatment of treatment-resistant depressive disorders using deep brain electrical stimulation.
