Mechanisms and potential applications of extracellular vesicles in bipolar disorder
10.3969/j.issn.1002-0152.2023.10.010
- VernacularTitle:细胞外囊泡在双相障碍中的机制和潜在应用
- Author:
Han JIANG
1
;
Xueyu QI
;
Xueli YU
;
Yan XU
;
Tao LI
Author Information
1. 浙江大学医学院附属精神卫生中心&杭州市第七人民医院(杭州 310013)
- Keywords:
Bipolar disorder;
Extracellular vesicles;
Exosomes;
Pathologic processes;
Neurocognitive disorders;
Inflammation;
Metabolism;
Biomarker;
Individualized treatment
- From:
Chinese Journal of Nervous and Mental Diseases
2023;49(10):631-635
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of bipolar disorder(BD)is unknown,and objective biomarkers with clinical guidance are lacking.Extracellular vesicles(EV)are lipid bilayer-enclosed vesicles that carry cargo from originating cells,influencing the processes of recipient cells.They are capable of crossing the blood-brain barrier and reflecting the ongoing processes in the central nervous system.Compelling data indicates that EV could mediate BD pathophysiological processes such as neurocognitive impairment,neuroinflammatory diffusion,and metabolic dysfunction.Therefore,EV has the potential to become a reliable biomarker and therapy for BD,providing new ideas for revealing the pathogenesis and clinical diagnosis and treatment of BD.
