Proton magnetic resonance spectroscopy in the ventromedial prefrontal lobe of adolescents with bipolar de-pression with anxiety symptoms
10.3969/j.issn.1002-0152.2023.10.005
- VernacularTitle:伴有焦虑症状青少年双相抑郁患者腹内侧前额叶氢质子磁共振波谱研究
- Author:
Chengji WANG
1
,
2
;
Yuan QU
;
Cheng ZHANG
;
Xiaoxiao TANG
;
Abula GULIBAKERANMU
;
Gaiyu TONG
;
Shaohong ZOU
Author Information
1. 石河子大学医学院
2. 新疆维吾尔自治区人民医院临床心理科(乌鲁木齐 830000)
- Keywords:
Adolescent;
Bipolar disorder;
Depressive episode;
Anxiety symptoms;
Proton magnetic resonance spectroscopy;
Neurometabolism
- From:
Chinese Journal of Nervous and Mental Diseases
2023;49(10):604-608
- CountryChina
- Language:Chinese
-
Abstract:
Objective Exploring the relationship between anxiety symptoms and neurometabolism in the ventrome-dial prefrontal cortex(vmPFC)of adolescents with bipolar depression.Methods Thirty-six adolescent patients with bi-polar depression were assessed and grouped by using the 14-item Hamilton anxiety rating scale(HAMA),including 20 pa-tients with anxiety symptoms and 16 patients without anxiety symptoms.The severity of depressive symptoms was assessed using the 24-Hamilton depression scale(HAMD),and 1H-magnetic resonance spectroscopy(1H-MRS)was used.The dif-ference of vmPFC neurometabolism between 2 groups was compared.Results Compared with the group without anxiety symptoms,the HAMD score[24.50(24.00,26.75)vs.23.00(22.00,24.00)]and the proportion of family history(40.0%vs.0)were significantly higher in the group with anxiety symptoms than in the group without anxiety symptoms(P<0.05).The level of mI/Cr was higher in the group with anxiety symptoms than that in the group without anxiety symptoms(0.58±0.12 vs.0.47±0.11),and the difference was significant(P<0.05).Cho/Cr and HAMD scores in patients with anxiety symptoms were positively correlated(r=0.589,P=0.006),and mI/Cr was negatively correlated with disease duration(r=-0.481,P= 0.032).Conclusions Anxiety symptoms in adolescent bipolar depression patients may be related to elevated levels of mI,a neurometabolite in the brain region of vmPFC.
