Research progress on the effects of glucagon-like peptide-1 receptor agonists in stroke
10.3969/j.issn.1002-0152.2023.09.007
- VernacularTitle:胰高血糖素样肽受体激动剂对脑卒中影响研究进展
- Author:
Yajing WANG
1
;
Penghua FANG
;
Zhenwen ZHANG
Author Information
1. 扬州大学临床医学院(扬州 225000)
- Keywords:
Glucagon-like peptide-1 receptor agonists;
Storke;
Diabetes;
Oxidative stress;
Neuronal apoptosis
- From:
Chinese Journal of Nervous and Mental Diseases
2023;49(9):549-553
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is a prevalent acute cerebrovascular disease associated with significant morbidity and mortality,which highly demand effective prevention and treatment strategies.Glucagon-like peptide-1 receptor agonists(GLP-1RA)is a novel type of antidiabetic drug that exerts hypoglycemic and weight loss effects on GLP-1 receptors.Additionally,GLP-1RA possess the potential to reduce infarction size and promote nerve recovery by inhibiting inflammation,oxidative stress,apoptosis,and improving blood-brain barrier permeability and other pathologies.This paper provides a comprehensive summary of the role of GLP-1 in stroke occurrence while also explores the underlying mechanisms by which GLP-1RA influences stroke pathogenesis.Furthermore,it briefly reviews the therapeutic efficacy of GLP-RA in managing stroke.
