Association between childhood trauma and plasma adiponectin levels in patients with depression
10.3969/j.issn.1002-0152.2023.09.004
- VernacularTitle:童年期创伤与抑郁症患者血浆脂联素水平关联研究
- Author:
Fanfan HUANG
1
;
Bufan LIU
;
Tianyu ZHAO
;
Na LI
;
Wenting LU
;
Wei WANG
;
Huan CHEN
;
Ran WANG
;
Yuanyuan GAO
;
Li YANG
;
Ruojia REN
;
Lulu YU
;
Cuixia AN
;
Xueyi WANG
Author Information
1. 河北医科大学第一医院精神卫生中心,河北省精神卫生研究所(石家庄 050031)
- Keywords:
Childhood trauma;
Depression;
Adiponectin;
Enzyme-linked immunosorbent assay;
Relevance
- From:
Chinese Journal of Nervous and Mental Diseases
2023;49(9):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between childhood trauma and plasma adiponectin levels in patients with depression.Methods A total of 121 patients with depression and 39 healthy controls(control group)were enrolled.Childhood trauma questionnaire(CTQ-SF)was used to assess the experience of childhood abuse and neglect,and the patients with depression were divided into trauma group(n=53)and non-trauma group(n=68)according to the CTQ-SF score.The 17-item Hamilton depression scale-17(HAMD17)and the Hamilton anxiety scale(HAMA)were used to evaluate the severity of depression and anxiety symptoms,respectively.Plasma adiponectin levels of subjects were measured by enzyme-linked immunosorbent assay.Results The plasma adiponectin level of trauma group[3.82(2.44,4.92)μg/mL]was significantly lower than that of non-trauma group[4.64(2.98,6.43)μg/mL,P=0.01]and the control group[6.29(4.54,7.51)μg/mL,P＜0.01].The plasma adiponectin level of non-trauma group was lower than that of the control group(P＜0.01).Correlation analysis showed that plasma adiponectin level in patients with depression was negatively correlated with childhood trauma(r=-0.34,P＜0.01).Multivariate linear regression analysis showed that plasma adiponectin level was negatively correlated with childhood trauma scores in patients with depression(β=-0.05,P＜0.01).Conclusions Patients with depression who have experienced childhood trauma have lower plasma levels of adiponectin,and childhood trauma may be associated with decreased plasma adiponectin levels in patients with depression.
