Research progress in the immune escape mechanism of Trichinella spiralis
10.3969/j.issn.1002-2694.2024.00.013
- VernacularTitle:旋毛虫免疫逃避机制的研究进展
- Author:
Yan-Hong QIAN
1
;
Shuai SONG
;
Xiao-Hui WEN
;
Chun-Ling JIA
;
Dian-Hong LYU
;
Zi-Guo YUAN
;
Sheng-Jun LUO
Author Information
1. 华南农业大学兽医学院,广州 510642
- Keywords:
Trichinella spiralis;
infection;
immune escape
- From:
Chinese Journal of Zoonoses
2024;40(1):70-75
- CountryChina
- Language:Chinese
-
Abstract:
Trichinosis is a global food-borne zoonotic parasitic disease caused by Trichinella spiralis(T.spiralis),which causes serious harm to animal production,and the public health safety of humans and animals.T.spiralis has a complex devel-opment history,and its entire life cycle is completed in the same host.To coexist with the host,it has evolved various immune escape mechanisms for avoiding immune clearance by the host,thus establishing long-term chronic infection.In this study,to aid in understanding the pathogenic mechanism of T.spiralis,the immune escape mechanism of Trichinella is discussed from three aspects:the molecular role of antigens in various stages,the immune regulatory effect on the host,and the formation of cysts to generate immune isolation.
