Molecular mechanism of the effects of alphaherpesvirus envelope glycoprotein I on virulence
10.3969/j.issn.1002-2694.2023.00.146
- VernacularTitle:α疱疹病毒囊膜糖蛋白gI影响病毒毒力的分子机制
- Author:
Yu-Lian PANG
1
,
2
,
3
;
Xu-Dong QIN
;
Ming-Shu WANG
;
An-Chun CHENG
Author Information
1. 四川农业大学动物医学院,成都 611130
2. 四川农业大学动物医学院,动物医学免疫学研究所禽病防治研究中心,成都 611130
3. 四川农业大学动物疫病与人类健康四川省重点实验室,成都 611130
- Keywords:
alphaherpesvirus;
glycoprotein I;
viral virulence
- From:
Chinese Journal of Zoonoses
2023;39(12):1202-1210
- CountryChina
- Language:Chinese
-
Abstract:
The alphaherpesvirus envelope glycoprotein I,encoded by the non-essential gene US7,plays an important role in the pathogenic mechanism of the virus.Recent studies have shown that envelope glycoprotein gI is important in the assembly of alpha herpesvirus particles and the diffusion of viral particles,by participating in secondary envelope coating and promoting in-tercellular transmission.The protein also has essential roles in promoting the axonal transport of the virus along neurons and the anti-host immune response,thereby affecting virulence.This article discusses the molecular mechanism through which gI affects the virulence of alpha herpes virus,thus providing a theoretical basis for in-depth study of the function of this protein.
