A Phase Contrast Microscopic Study on the Induction of Cellular Deformation in Mast Cells.
- Author:
Kum Duck CHOI
1
;
Yung Keun OH
;
Dal Uck PARK
;
Kyu Soon RHIM
;
Tong Hun CHO
Author Information
- Publication Type:Original Article
- MeSH: Animals; Colchicine/*pharmacology; Mast Cells/*drug effects/*radiation effects; Microscopy, Phase-Contrast; *Panax; Plant Extracts/pharmacology; *Plants, Medicinal; *Radiation Injuries, Experimental; Rats; Saponins/*pharmacology
- From:Yonsei Medical Journal 1966;7(1):1-6
- CountryRepublic of Korea
- Language:English
- Abstract: The influence of colchicine, colcemid, ginseng-alcohol extract, saponin, garlic alcohol-ether extract, and X-irradiation on free floating peritoneal mast cells were studied in rats by means of a phase contrast microscope. After the intraperitoneal injection of colchicine or colcemid the mast cells of the albino rat peritoneal fluid show an altered morphology. Ginseng-alcohol extract, allicin extracted from garlic, and X-irradiation do not elicit this cytological response.Mast cells exposed to saponin exhibit a severe destruction and degranulation. The relation of the mast cell-damaging agents, metabolic poisons, and X1-irradiation to the mast cell response is discussed with reference to the morphological changes. These are compared with the data of Padawer (1960, 1966).
