Research progress of microRNA-mediated immune function of CD4+T cells subsets in immune thrombocytopenia
10.3969/j.issn.1000-484X.2024.03.038
- VernacularTitle:MicroRNA调节免疫性血小板减少症CD4+T细胞亚群免疫功能的研究进展
- Author:
Hui SONG
1
;
Yihui GUO
;
Jiawei XU
;
Qing ZENG
;
Weimin CHENG
Author Information
1. 广西中医药大学研究生院,南宁 530222
- Keywords:
MicroRNA;
Immune thrombocytopenia;
CD4+T cells subsets
- From:
Chinese Journal of Immunology
2024;40(3):663-667
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA(miRNA)is a kind of small non-coding single stranded RNA that can participate in multiple biological processes.It also plays an important role in regulating the immune function of the body.Immune thrombocytopenia(ITP)is an autoim-mune disease,whose cause and deterioration are closely related to miRNA regulates immune function of CD4+T cells subsets.In ITP patients,different expression of miRNA can affect the immune function of CD4+T cells subsets,which causes not only unbalanced ex-pression of Th1/Th2,Th17/Treg and excessive differentiation of TFH,but also abnormal cytokine secretion furthermore.This paper summarizes the unbalanced mechanism of miRNA regulating immune function of CD4+T cells subsets in ITP,so as to provide inspira-tion for exploring the immunology and immunotherapy of ITP.
