Research progress of costimulatory signals and cardiovascular diseases
10.3969/j.issn.1000-484X.2024.03.037
- VernacularTitle:共刺激信号与心血管疾病的研究进展
- Author:
Changle DU
1
;
Yu WANG
;
Renbiao MEI
Author Information
1. 安徽理工大学医学院基础医学系,淮南 232001
- Keywords:
Costimulatory signals;
Cardiovascular disease;
Inflammation;
Signaling pathway
- From:
Chinese Journal of Immunology
2024;40(3):656-662
- CountryChina
- Language:Chinese
-
Abstract:
Chronic inflammation is the pathological basis for the development of cardiovascular diseases.Immune cells domi-nated by T cells can secrete pro-inflammatory factors to mediate inflammation and affect the progress of cardiovascular diseases.The co-stimulatory signals is the second signal of T cell activation,which can enhance or inhibit the signal transmission of T cell antigen re-ceptor(TCR)by Phosphatidylinositol 3-kinase(PI3K),mitogen activated protein kinase(MAPK)and C-Jun N-terminal kinases(JNK),which play an important role in cardiovascular disease by regulating T cell immune function,the release of inflammatory cyto-kines,and the production of extracellular matrix.This article describes the transmission mechanism of costimulatory signals and their correlation with cardiovascular diseases,in order to provide new ideas for immunotherapy of cardiovascular diseases.
