miR-155/GATA3/CD4+T cell pathway regulates pathogenesis of allergic rhinitis

VernacularTitle:miR-155/GATA3/CD4+T细胞通路对变应性鼻炎发病机制的调控
Author: Rongrong LI ^{1
,

2
,

3} ; Shenhong QU ; Shaojie ZHANG ; Xueying HUANG ; Ziling ZHONG
Author Information

1. 右江民族医学院,百色 533000
2. 广西壮族自治区人民医院耳鼻咽喉头颈科,南宁 530021
3. 榆林市星元医院,榆林 719000
Keywords: Allergic rhinitis; miR-155; GATA3; CD4+T cell; ILC2
From: Chinese Journal of Immunology 2024;40(3):629-635
CountryChina
Language:Chinese
Abstract: Allergic rhinitis(AR)is a type Ⅰ allergic reaction,which mediated by immunoglobulin E immediately when an individual with a special constitution is exposed to a same allergen for second time,whose pathogenesis has not been clarified yet,and closely related to genes,immune cells and cytokines.Pathogenesis of AR become more deeper and more accurate due to rapid develop-ment of molecular biology and second-generation gene sequencing technology.Current studies have found that miR-155 and transcrip-tion factor GATA3 have important regulatory effects on occurrence and development of AR,then affect dominant differentiation of CD4+T lymphocytes and proliferation of ILC2.This article discusses and reviews pathogenesis of AR,which mainly focuses on miR-155/GATA3 pathway and effects of related upstream genes and downstream regulatory substances.