Research progress on role and mechanism of PA28γ in immune-related diseases
10.3969/j.issn.1000-484X.2024.01.030
- VernacularTitle:PA28γ在免疫相关疾病中的作用及机制研究进展
- Author:
Chongying SU
1
;
Jialu NIU
;
Junjie GU
;
Jing LI
Author Information
1. 四川大学口腔疾病防治全国重点实验室,成都 610041
- Keywords:
PA28γ;
Inflammation;
Tumor;
Viral infection;
Therapeutic target
- From:
Chinese Journal of Immunology
2024;40(1):192-201
- CountryChina
- Language:Chinese
-
Abstract:
Proteasome activator PA28γ,also known as Ki antigen,REGγ or PSME3,is first found as Ki antigen in the serum of a patient with systemic lupus erythematosus,which belongs to 11S proteasome activator family together with PA28α and PA28β.In the amino acid sequence,PA28γ has 25%homology with PA28α and PA28β and its seven-subunit homomer is a 20S proteasome acti-vator,which mainly exists in the nucleus and participates in ubiquitin and ATP-dependent or independent protein degradation.More and more studies have reported the role of PA28γ in human immune-related diseases.This article reviews the function of PA28γ as a proteasome activator and its role in immune-related diseases including cancer,inflammation and virus infection-related diseases and other diseases in recent years,so as to reveal the role of PA28γ in the occurrence and development of immune-related diseases and its potential as a target for immunotherapy.
