Research progress of CD4+T cells in influenza virus infection-induced cytokine storm and acute lung injury
10.3969/j.issn.1000-484X.2023.12.035
- VernacularTitle:CD4+T细胞在流感病毒感染诱发细胞因子风暴及急性肺损伤中的研究进展
- Author:
Jiawang HUANG
1
;
Xinyue MA
;
Mengchen ZHU
;
Weirong LIU
;
Yulu CHEN
;
Ling LI
Author Information
1. 湖南中医药大学中西医结合学院,长沙 410208
- Keywords:
CD4+T cells;
Influenza virus;
Cytokine storm;
Acute lung injury
- From:
Chinese Journal of Immunology
2023;39(12):2666-2671
- CountryChina
- Language:Chinese
-
Abstract:
As the main weapon of cellular immunity,CD4+ T cells play a vital role in controlling and eliminating infections,and are an important barrier for the body to resist infections.Respiratory tract infectious diseases caused by influenza virus infection have extremely high infectivity,morbidity and mortality.The infection mechanism is relatively complicated and has not been fully ex-plained.The exuberant immune response induced by the body after influenza virus infection is described as a"cytokine storm"which is related to pro-inflammatory cytokines and tissue damage,which may eventually lead to acute lung injury.Therefore,this article sum-marizes the current research progress,focusing on the mechanism of CD4+T cells in the cytokine storm induced by influenza virus in-fection and the impact of acute lung injury,providing relevant ideas and theoretical guidance for follow-up research,with a view to the disease caused by influenza virus bring new and effective methods of diagnosis and treatment.
