Analysis of expression and clinical significance of SHCBP1 gene in lung adenocarcinoma based on bioinformatics
10.3969/j.issn.1000-484X.2023.12.025
- VernacularTitle:基于生物信息学方法分析SHCBP1基因在肺腺癌中的表达及临床意义
- Author:
Yanyan LIAN
1
;
Yuxiang WAN
;
Liling LI
;
Chunguang ZHANG
;
Jinchang HUANG
Author Information
1. 北京中医药大学第三附属医院,北京 100029
- Keywords:
SHCBP1;
Lung adenocarcinoma;
Immune cell infiltration;
GEPIA database;
TIMER database
- From:
Chinese Journal of Immunology
2023;39(12):2606-2612
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expression and clinical significance of SHC SH2-binding protein 1(SHCBP1)in lung adenocarcinoma(LUAD).Methods:Oncomine,TIMER,UALCAN,GEPIA,Kaplan-Meier plotter and STRING databases were used to explore the effect of SHCBP1 on progression and immune infiltration of LUAD.Results:Expression of SHCBP1 mRNA in LUAD tissue was significantly higher than that in normal lung tissue(P<0.05).Expression of SHCBP1 mRNA was significantly increased in LUAD patients with smoking history,nodal metastasis,late clinical stage and TP53 mutation(P<0.05).Survival analysis by GEPIA and Kaplan-Meier plotter databases showed that LUAD patients with high SHCBP1 mRNA expression had a lower overall survival rate(P<0.05).SHCBP1 mRNA was correlated with immune cell infiltration,immune cell markers and immune checkpoint expression in LUAD.Conclusion:High expression of SHCBP1 is related to poor prognosis and tumor immune infiltration of LUAD patients.
