Clinical research on sensitivity to thyroid hormones and its association with nutrition and metabolism: progress and perspectives
10.3760/cma.j.cn115822-20231031-00051
- VernacularTitle:甲状腺激素敏感性与营养代谢的研究进展
- Author:
Zihan CHEN
1
;
Yuanmeng LI
;
Naishi LI
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院内分泌科 国家卫生健康委员会内分泌重点实验室，北京 100730
- Keywords:
Sensitivity to thyroid hormones;
Metabolic syndrome;
Bone mineral density;
Vitamin D
- From:
Chinese Journal of Clinical Nutrition
2024;32(1):57-64
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid hormones are crucial for energy metabolism. Thyroid dysfunction is closely related to a variety of metabolic disorders. However, evaluation relying solely on thyroid function indicators may come up short, considering the complex relationship between thyroid hormones and metabolic issues. There has been a growing recognition of sensitivity to thyroid hormones as a measure of thyroid function complementary to traditional indices. The indicators of thyroid hormone sensitivity include free triiodothyronine/free thyroxine, thyrotroph thyroxine resistance index, thyroid-stimulating hormone index and thyroid feedback quantile-cased index. It has been reported that impaired sensitivity to thyroid hormones can potentially interact with various nutritional imbalances and metabolic abnormalities, such as metabolic syndrome, osteoporosis and decreased vitamin D, which are not only of concern to those with thyroid dysfunction, but also to euthyroid individuals in terms of prevention and prophylaxis. With the aim of providing comprehensive insights, this review is intended to systematically summarize the existing evidence on the association between sensitivity to thyroid hormones and metabolic disorders.
