Effect of calorie-restricted diet combined with intestinal microecological preparation on clinical outcomes in overweight/obese infertile patients
10.3760/cma.j.cn115822-20230719-00006
- VernacularTitle:CRD联合微生态制剂对超重和肥胖不孕患者临床结局的影响
- Author:
Ying ZHONG
1
;
Hong LUO
;
Shubiao HAN
;
Feng ZHOU
;
Qi SONG
;
Tianping LI
;
Hailan SUN
Author Information
1. 重庆市妇幼保健院 重庆医科大学附属妇女儿童医院临床营养科 401147
- Keywords:
Calorie-restricted diet;
Intestinal microbiome;
Overweight;
Obesity;
Embryo transfer
- From:
Chinese Journal of Clinical Nutrition
2023;31(6):336-342
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of calorie-restricted diet (CRD) combined with intestinal microecological preparation on the clinical outcomes in overweight/obese infertile patients undergoing frozen-thawed embryo transfer (FET) cycle.Methods:252 overweight/obese infertile patients who met the inclusion and exclusion criteria were included and divided into overweight intervention group, overweight control group, obese intervention group and obese control group, according to body mass index (BMI) and whether or not they received nutritional intervention. Clinical outcome indexes and changes in anthropometry and body composition before and after intervention were compared across all groups.Results:Body mass, BMI, body fat percentage, waist-to-hip ratio and visceral fat grade were significantly decreased after nutritional intervention in both overweight and obese intervention groups (both P<0.001). Among overweight patients, follicle count [(17.89±4.97) vs. (16.22±5.41), P=0.027], live births [(0.64±4.77) vs. (0.36±8.61), P=0.005] and the rate of live birth (47.19% vs. 30.19%, P=0.005) were significantly increased in the intervention group compared with the control group. Among obese patients, live births [(0.89±3.79) vs. (0.48±3.69), P=0.040] and the rate of live birth (64.29% vs. 37.93%, P=0.047) were significantly increased in the intervention group. Conclusion:In overweight and obese infertile patients undergoing FET cycle, the nutritional intervention of CRD combined with complex intestinal microecological preparation can help reduce weight and body fat, and may be beneficial to improving the success rate of assisted reproductive technology.
