Clinical application of mixed-oil fat emulsion in preterm infants with necrotizing enterocolitis
10.3760/cma.j.cn115822-20230312-00037
- VernacularTitle:多种油脂肪乳在早产儿坏死性小肠结肠炎的临床应用研究
- Author:
Zixian LI
1
;
Liangliang LI
;
Xinyue LUO
;
Hui SHAO
;
Xianghong LI
Author Information
1. 青岛大学附属医院新生儿科 266555
- Keywords:
Parenteral nutrition;
Mixed-oil fat emulsion;
Fish-oil fat emulsion;
Preterm infants;
Necrotizing enterocolitis
- From:
Chinese Journal of Clinical Nutrition
2023;31(5):300-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical application of multi-oil fat emulsion (SMOF) in preterm infants with necrotizing enterocolitis (NEC).Methods:Preterm infants with NEC admitted to the Neonatal Intensive Care Unit in our hospital between January 2017 and December 2022 were retrospectively included. According to the type of fat emulsion used, they were divided into SMOF group and medium and long chain triglycerides (MCT/LCT) group. The data of two groups were compared and analyzed.Results:A total of 69 preterm infants were included, 34 in the SMOF group and 35 in the MCT/LCT group. There were no significant differences between the two groups in the levels of total bilirubin, indirect bilirubin, direct bilirubin, bile acid and γ-glutamyl transferase ( P>0.05). There were no significant differences between the two groups in triglyceride, low density lipoprotein and total cholesterol ( P>0.05). There were no significant differences between the two groups in the C reactive protein level, procalcitonin level, and the time to normal C reactive protein ( P>0.05). There were no significant differences in incidence of complications between the two groups, including parenteral nutrition-related cholestasis, bronchopulmonary dysplasia, retinopathy of prematurity, and brain injury ( P>0.05). Conclusions:Compared with MCT/LCT, the application of SMOF did not show significant effect on liver function, inflammation, or incidence of complications (parenteral nutrition-related cholestasis, bronchopulmonary dysplasia and retinopathy of prematurity) in preterm infants with NEC. Multi-center studies with larger sample size are needed for further investigation.
