Study on the stability of different fat emulsions in parenteral nutrition

Sitong Liu; Da Zhou; Hui Wang; Shuyu Cao; Hua Chen; Ting SI; Jing Chen; Xiaotong Jin; Xianghong YE; Xinying Wang

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Study on the stability of different fat emulsions in parenteral nutrition

VernacularTitle:不同脂肪乳在肠外营养液中稳定性的研究
Author: Sitong LIU ¹ ; Da ZHOU ; Hui WANG ; Shuyu CAO ; Hua CHEN ; Ting SI ; Jing CHEN ; Xiaotong JIN ; Xianghong YE ; Xinying WANG
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1. 解放军东部战区总医院普通外科，南京　210002
Keywords: Parenteral nutrient solution; Medium-chain triglyceride fat emulsion; Long-chain triglyceride fat emulsion
From: Chinese Journal of Clinical Nutrition 2023;31(5):290-293,306
CountryChina
Language:Chinese
Abstract: Objective:To investigate the stability of fat emulsions after the preparation of parenteral nutrient solution under different storage conditions.Methods:Standardized parenteral nutrient solution was used to prepare a total of 24 bags of nutrient solution with the same formula, except for that Group A (12 bags) contains 20% of medium and long chain fat emulsion (C6-24) while Group B contains 20% of C8-24. The preparations were stored under 2-8℃, 23-25℃, and 35-37℃ and were examined at 24h, 48h and 72h after preparation. The appearance, average size of fat particles, pH value of nutrient solution, and lipid peroxidation were investigated.Results:After storage at 4℃, 25℃ and 36℃ for 24h, 48h and 72h respectively, both groups of preparations showed no obvious change in appearance. There was no significant difference in pH ( P>0.05) nor lipid peroxidation ( P>0.05). Conclusion:Both kinds of fat emulsion are stable in terms of pH value, fat particle size and lipid peroxidation, and can be used for patients receiving intravenous nutrition support.