Research progress of uterine endometrial epithelial cell organoids in the field of reproduction
10.12092/j.issn.1009-2501.2024.05.013
- VernacularTitle:子宫内膜上皮细胞类器官在生殖领域的研究进展
- Author:
Zhiwen CAO
1
;
Guijun YAN
Author Information
1. 南京大学医学院附属鼓楼医院生殖医学和妇产医学中心,南京 210000,江苏
- Keywords:
endometrial epithelial cells;
organ-oids;
drug screening
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(5):576-582
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,significant progress has been made in the study of endometrial epitheli-al organoids in the field of reproduction.Traditional two-dimensional cell culture models and animal ex-periments fail to accurately replicate the three-di-mensional structure and physiological functions of the endometrium,limiting the in-depth exploration of its normal physiological mechanisms and related disease mechanisms.Emerging organoid technolo-gies have provided new avenues for research.These organoids,formed by self-organization of stem cells or progenitor cells in a three-dimensional culture system,faithfully recapitulate the character-istics of endometrial glands in situ.Not only can these organoid models mimic the changes in the endometrium at different stages of the menstrual cycle,but they can also simulate the interaction be-tween the fertilized embryo and the endometrium.Moreover,organoid systems have become essential tools for fundamental research in the field of repro-duction and for disease research,including studies related to reproductive biology,drug screening and development,disease mechanism exploration,drug action mechanisms,drug combination therapies,and targeted therapies.These studies have provid-ed novel insights and methods for a deeper under-standing of the biological properties of the endome-trium,its disease mechanisms,and the develop-ment of therapeutic strategies for related disorders.
