Comparison of clinical effectiveness and safety between generic and branded dienogest tablets in the treatment of endometriosis
10.12092/j.issn.1009-2501.2024.05.007
- VernacularTitle:两种地诺孕素治疗子宫内膜异位症的临床疗效及不良反应对比
- Author:
Qian LIU
1
;
Jianing ZHANG
;
Shuang ZHANG
;
Qinglan LIU
;
Baoyin ZHANG
;
Nan SUN
Author Information
1. 郑州大学第三附属医院药学部,郑州 450052,河南
- Keywords:
dienogest;
generic drugs;
branded drugs;
endometriosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(5):527-534
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To evaluate the clinical effective-ness and safety of generic and branded dienogest in the treatment of endometriosis.so as to provide the basis for clinical use of dienogest.MEHTODS:The data of patients admitted to Third Affiliated Hospital of Zhengzhou University from August 2022 to August 2023 who received dienogest(2 mg/d,orally,for 6 months)for treatment of endometrio-sis were collected.The clinical efficacy and adverse reactions of generic drugs and original drugs in the treatment of endometriosis-related pain were com-pared through follow-up surveys of the two groups of patients at 3 months and 6 months respectively.RESULTS:There was highly significant reduction in pelvic pain in both groups with mean of similar in generic group(34.0±3.0)mm and branded group(34.5±3.9)mm.The most frequent drug-related ad-verse effects in generic dienogest was vaginal bleeding(93%)which was no statistical difference with branded dienogest(90%).CONCLUSION:The generic and branded dienogest have the same clini-cal effectiveness and similar safety.
