Research progress on the regulation of endometriosis by PI3K/Akt signaling pathway and the intervention effect of traditional Chinese medicine
10.12092/j.issn.1009-2501.2024.05.004
- VernacularTitle:PI3K/Akt信号通路调控子宫内膜异位症及中药干预作用研究进展
- Author:
Quanyang LI
1
;
Yafang HAO
;
Guotai WU
;
Ruiqiong WANG
Author Information
1. 甘肃中医药大学药学院,兰州 730000,甘肃
- Keywords:
endometriosis;
phosphoinositide 3-kinase/protein kinase B signaling pathway;
tradi-tional Chinese medicine;
classic formula
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(5):501-511
- CountryChina
- Language:Chinese
-
Abstract:
Endometriosis(Endometriosis,EMs)is a disease caused by abnormal colonization of the endometrial stroma or glands to sites other than the coated mucosa of the uterine cavity.Phospho-lipid inositol 3 kinase(phosphoinositide 3-kinase,PI3K)/protein kinase B(protein kinase B,Akt)sig-naling pathway is involved in the process of focal blood vessel formation,cell autophagic apoptosis,migration and invasion,and is one of the classic pathways regulating the pathological characteris-tics of EMs.The characteristics of multi-compo-nent,multi-target and multi-pathway of TCM have significant advantages in the treatment of EMs.Some TCM active components and TCM com-pounds can interfere with the PI3K/Akt signaling pathway,thus inhibiting the treatment of endome-triotic tissues,reducing pain and alleviating fibrotic lesions.By explaining the connection between the key targets of PI3K/Akt signaling pathway and EMs,this paper summarizes and summarizes the re-search status of EMs by regulating PI3K/Akt signal pathway in home and abroad,aiming to provide a new perspective and idea for the use of traditional Chinese medicine and compound to treat EMs.
