Progress in the application of non-peptide gonadotropin-releasing hormone antagonist in the treatment of uterine fibroid
10.12092/j.issn.1009-2501.2024.05.001
- VernacularTitle:非肽类促性腺激素释放激素拮抗剂在子宫肌瘤治疗中的应用研究进展
- Author:
Yunxi ZHENG
1
;
Xiaofang YI
;
Congjian XU
Author Information
1. 复旦大学附属妇产科医院,上海 200011
- Keywords:
gonadotropin releasing hormone an-tagonists;
uterine fibroid;
treatment;
effectiveness;
safety
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(5):482-487
- CountryChina
- Language:Chinese
-
Abstract:
Non-peptide gonadotropin-releasing hormone antagonist(GnRH-antagonist)is a highly efficient and selective antagonist of GnRH receptor.The oral preparations(Elagolix,Relugolix and Linza-golix)had been approved for listing abroad.It shows efficacy in reducing the size of uterine fi-broid and controlling heavy bleeding.Appropriate combination of'add-back'therapy could improve the safety in medical application and patient com-pliance.Compared with other hormonal pharma-ceuticals,oral GnRH-antagonists showed promising prospects in the treatment of uterine fibroid.
