Advances in the study of mesenchymal stem cells in obstructive sleep apnea hypoventilation syndrome
10.12092/j.issn.1009-2501.2024.01.013
- VernacularTitle:间充质干细胞对OSAHS病理生理调节机制的研究进展
- Author:
Jinhui XU
1
;
Hongmei YUE
;
Yating LI
;
Miaomiao LIU
;
Xingdong WU
;
Haobin ZHU
Author Information
1. 兰州大学第一临床医学院,兰州 730000,甘肃
- Keywords:
obstructive sleep apnea hypoventila-tion syndrome;
mesenchymal stem cells;
mecha-nism of action;
research progress
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(1):114-120
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells(MSCs)are self-regenerating,rapidly proliferating pluripotent stem cells that depend primarily on their derived pro-angiogenic,inflammatory regulatory,and tro-phic factors to exert beneficial effects that attenu-ate deleterious inflammatory responses,reduce vascular damage,and promote tissue repair and re-generation.Obstructive sleep apnea hypoventila-tion syndrome(OSAHS)is a chronic disorder marked by oropharyngeal collapse during sleep,re-sulting in transient reduced airflow,large fluctua-tions in intrathoracic pressure,and intermittent hy-poxia and hypercapnia.OSAHS subsequently cyto-kine-mediated inflammatory cascades,oxidative stress,and ischemia,recruit MSCs from inflamed and damaged tissues through MSCs-derived of anti-inflammatory and pro-angiogenic factor activity,re-duce hypoxia,suppress inflammation,promote re-generation,and prevent fibrosis in OSAHS-injured tissues.In this paper,we will describe the patho-genesis of inflammation,oxidative stress,fibrosis and ischemia from the perspective of OSAHS,high-lighting the current research progress on MSCs-de-pendent regulation of OSAHS-related pathology.
