Risk factors of apathy and correlations with cognitive function in patients with hypertension combined with cerebral small vessel disease
10.13929/j.issn.1672-8475.2024.03.004
- VernacularTitle:高血压合并脑小血管病患者情感淡漠危险因素及其与认知功能的相关性
- Author:
Jiali CAO
1
,
2
;
Tianran WANG
;
Yang LIU
;
Duo ZHANG
;
Jin'e XU
;
Chong LIU
;
Shumei WANG
;
Yongchang HAN
;
Lulu YANG
Author Information
1. 承德医学院研究生学院,河北 承德 067000
2. 保定市第一中心医院医学影像一科,河北 保定 071000
- Keywords:
cerebrovascular disorders;
apathy;
magnetic resonance imaging;
prospective studies
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(3):145-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of apathy and correlations with cognitive function in patients with hypertension combined with cerebral small vessel disease(CSVD).Methods Totally 141 patients with hypertension combined with CSVD were prospectively enrolled and were divided into apathy group(n=43)and non-apathy group(n= 98)according to neuropsychiatric inventory-apathy scale(NPI-Apathy)scores.The general data,imaging marker scores and total imaging burden scores were compared between groups.In hypertension combined with CSVD patients,multivariate logistic regression analysis was performed to screen the independent risk factors of apathy,and Spearman correlation analysis was also performed to observe the correlation of apathy and cognitive function.Results The patients'age,high density lipoprotein cholesterol(HDL-C),Fazekas scores of lateral periventricular white matter hyper-intensity(WMH),cerebral microbleed of depth/infratentorial and total imaging burden scores of apathy group were all higher,while mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)scores were both lower than those of non-apathy group(all P＜0.05).HDL-C and Fazekas scores of lateral periventricular WMH were both independent risk factors for apathy(both P＜0.05),while NPI-Apathy scores were moderately negatively correlated with cognitive function in patients with hypertension combined with CSVD(r=-0.543,-0.484,both P＜0.001).Conclusion HDL-C and Fazekas scores of lateral periventricular WMH were both independent risk factors for apathy in patients with hypertension combined with CSVD.The more severe the apathy,the lower the cognitive function.
