Changes in functional connectivity of raphe nucleus in patients with first-episode depression complicated with suicidal ideation
10.13929/j.issn.1672-8475.2024.01.005
- VernacularTitle:首发抑郁症伴自杀意念患者中缝核功能连接的改变
- Author:
Yu JIANG
1
;
Yuan CHEN
;
Shaoqiang HAN
;
Ruiping ZHENG
;
Bingqian ZHOU
;
Shuying LI
;
Jingliang CHENG
Author Information
1. 郑州大学第一附属医院磁共振科,河南郑州 450052
- Keywords:
depressive disorder;
suicide;
functional connectivity;
raphe nuclei;
magnetic resonance imaging;
prospective studies
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(1):22-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes in functional connectivity(FC)of raphe nucleus in patients with first-episode depression complicated with suicidal ideation(SI).Methods Ninety-eight first-episode depression patients were prospectively enrolled and assigned into SI group(n=56)or non SI group(n=42)based on complicated with SI or not,while 47 healthy volunteers were recruited as control group.Resting-state functional MRI was performed.FC between dorsal raphe nucleus(DRN),median raphe nucleus(MRN)and the whole brain were analyzed and compared among 3 groups and between each 2 groups,and the correlations of FC of different brain regions with clinical data of SI group were explored.Results Compared with control group,FC between DRN and left cerebellum and left putamen in SI group and non SI group decreased(all P＜0.05),between MRN and right inferior temporal gyrus increased but between MRN and left inferior frontal gyrus,right superior occipital gyrus,left inferior parietal lobule,left putamen decreased(all P＜0.05).FC between DRN and left putamen in SI group was higher than that in non SI group(P＜0.05).FC between MRN and right central posterior gyrus of SI group increased compared with that in the rest 2 groups(both P＜0.05).FC between MRN and left putamen in SI group was positively correlated with body mass score of Hamilton depression scale-24(HAMD-24)(rs=0.297,P=0.026).Conclusion Abnormal changes of FC between raphe nucleus and cortex,also between raphe nucleus and subcortical area occurred,and FC between MRN and left putamen positively correlated with body mass score of HAMD-24 in patients with first-episode depression complicated with SI.
