Combination of diffusion weighted imaging and dynamic contrast-enhanced MRI for predicting recurrence of hepatocellular carcinoma after TACE combined with radiofrequency ablation
10.13929/j.issn.1672-8475.2024.01.004
- VernacularTitle:弥散加权成像联合动态增强MRI预测肝细胞癌经TACE联合射频消融治疗后复发
- Author:
Zhouchao HU
1
;
Xiaodong ZHANG
;
Nannan YU
;
Benbao CHEN
Author Information
1. 浙江省舟山医院介入诊疗中心,浙江舟山 316021
- Keywords:
carcinoma,hepatocellular;
chemoembolization,therapeutic;
radiofrequency ablation;
magnetic resonance imaging
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(1):17-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of combination of diffusion weighted imaging(DWI)and dynamic contrast-enhanced MRI(DCE-MRI)for predicting recurrence of hepatocellular carcinoma(HCC)after TACE combined with radiofrequency ablation.Methods Date of 80 HCC patients who underwent TACE combined with radiofrequency ablation were retrospectively analyzed.Abdominal DWI and DCE-MRI were performed 10 days before as well as 20,60 and 90 days after treatment.The sensitivity,specificity and accuracy of combination of DWI and DCE-MRI for predicting recurrence of HCC 20 days after TACE combined with radiofrequency ablation were calculated,and receiver operating characteristic(ROC)curve was drawn to evaluate the efficacy of apparent diffusion coefficient(ADC)value for predicting recurrence of HCC 20 days after treatment.Results Patients with HCC were divided into stable group(n=47)and progressive group(n=33)according to modified response evaluation criteria in solid tumors.Twenty days after TACE combined with radiofrequency ablation,most HCC lesions in stable group presented as uneven DWI signals and high ADC signals without enhancement,while those in progressive group mainly presented as high DWI signals and low ADC signals with mild enhancement.The sensitivity,specificity and accuracy of combination of DWI and DCE-MRI for predicting recurrence of HCC 20 days after TACE combined with radiofrequency ablation was 97.75％(87/89),92.31％(24/26)and 96.52％(111/115),respectively,and the AUC of ADC value was 0.82.Taken 1.42X10-3 mm2/s as the cutoff value of ADC,the sensitivity and specificity of ADC value for predicting recurrence of HCC 20 days after TACE combined with radiofrequency ablation was 72.13％and 82.25％,respectively.Conclusion Combination of DWI and DCE-MRI had certain value for predicting recurrence of HCC after TACE combined with radiofrequency ablation,and ADC could be used as an effective predicting index.
