Comparison on TACE+microwave ablation+programmed death-1 and TACE+microwave ablation for treating primary hepatic carcinoma
10.13929/j.issn.1672-8475.2024.01.002
- VernacularTitle:比较TACE+微波消融+程序性死亡受体-1与TACE+微波消融治疗原发性肝癌
- Author:
Chang DONG
1
;
Wei LI
;
Wenling MAN
;
Weiwei SUN
;
Po YANG
Author Information
1. 哈尔滨医科大学附属第四医院介入血管外科,黑龙江哈尔滨 150001
- Keywords:
liver neoplasms;
ablation techniques;
chemoembolization,therapeutic;
programmed cell death 1 receptor
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(1):7-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the value of TACE+microwave ablation(MWA)+programmed death-1(PD-1)and TACE+MWA for treating primary hepatic carcinoma(PHC).Methods Data of 80 PHC patients who underwent TACE+MWA+PD-1(observe group)or TACE+MWA treatment(control group)were retrospectively analyzed(each n=40).The baseline data,therapeutic efficacy of PHC and complications were compared between groups.Results No significant difference of baseline data was found between groups(all P＞0.05).The objective response rate(ORR)of observe group and control group was 90.00％and 72.50％,respectively,while the disease control rate(DCR)was 97.50％and 95.00％,respectively,with no significant difference between groups(both P＞0.05).The median overall survival(OS)of observe group and control group was 30.80 months and 15.70 months,respectively,while the median progression free survival(PFS)was 23.35 months and 6.80 months,respectively.OS and PFS of observe group were both longer than those of control group(both P＜0.05).No significant difference of the incidence of complications was detected between groups(all P＞0.05),and all were improved after symptomatic treatment.Conclusion TACE+MWA+PD-1 was superior to TACE+MWA for treating PHC.
