An in vitro evaluation of the hydromechanical properties on transcatheter edge-to-edge repair
10.3969/j.issn.1004-8812.2024.02.005
- VernacularTitle:经导管缘对缘修复二尖瓣的体外流体力学性能评价
- Author:
Hao WANG
1
;
Da ZHU
;
Zhi-Qian LU
;
Zhao-Ming HE
;
Li LIU
;
Xiang-Bin PAN
Author Information
1. 江苏大学电气信息工程学院,江苏镇江 212013
- Keywords:
Functional mitral regurgitation;
Transcatheter edge-to-edge repair;
Test and assessment of heart valve in vitro
- From:
Chinese Journal of Interventional Cardiology
2024;32(2):89-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method for testing isolated mitral valve in vitro and quantitatively evaluate the effect of transcatheter edge-to-edge repair technology(TEER)on functional mitral regurgitation(FMR)(non-A2-P2 regurgitation).Methods In this study,an FMR(non-A2-P2 regurgitation)model was developed by dilating the annulus orifice and displacing the papillary muscle in isolated porcine mitral valve.The hydrodynamics characteristics of 6 valves were tested by a pulsatile flow testing system under different physiological and pathological conditions before and after TEER.Results The results show that the valve regurgitation improved from moderate-severe[regurgitant fraction(60.2±17.5)％]to mild-moderate[regurgitant fraction(34.7±12.0)％]by repair(P＜0.001).The EOA[(3.8±1.6)cm2 vs.(2.2±0.5)cm2,P＜0.001]and the forward cross valve pressure difference[(1.8±1.3)mmHg vs.(3.8± 1.8)mmHg,P＜0.001],which characterize the forward flow performance of the valve,were compared before and after repair,and the differences were statistically significant.At the same time,the repair caused valve stenosis(the effective orifice area decreased by 40％and the positive differential pressure increased by 110％),but the valves was still within the normal physiological range,and no iatrogenic stenosis was caused.Conclusions It can be seen that TEER has an effect on FMR.This study provides validation and evaluation methods in vitro for expanding indications and improving TEER,and reference for developing standards of transcatheter valve repair testing in vitro.
