Research progress on the mechanism of circular RNA involved in platinum resistance in ovarian cancer
- VernacularTitle:环状RNA参与卵巢癌铂耐药相关机制的研究进展
- Author:
Bin-Xin LIU
1
;
Ya-Dan FAN
;
Chun-Yan LYU
;
Zi-Man MEI
;
Qing-Chun DENG
Author Information
- Keywords: circular RNA; ovarian cancer; platinum resistance; mechanism; review
- From: Journal of Regional Anatomy and Operative Surgery 2024;33(2):179-182
- CountryChina
- Language:Chinese
- Abstract: Ovarian cancer has become the most lethal gynecological tumor due to the difficulty in early diagnosis,the late stage when diagnosed and the high recurrence rate.Resistance to platinum-based anti-tumor chemotherapy drugs is an important reason for the poor prognosis of ovarian cancer.circular RNA(circRNA)is more stable than mRNA in cells due to its special structure,and it is involved in the regulation of the occurrence,development and chemotherapy resistance of a variety of tumors.circRNA can be used as a competing endogenous RNA(ceRNA)of miRNA to bind to proteins,and regulates the phenotypic polarization of macrophages,it can also be used as an exosomal circRNA to regulate the sensitivity of platinum resistance in ovarian cancer.circRNA is expected to be a new marker of platinum resistance and a new target for the treatment of platinum resistance.In order to further explore the relationship between circRNA and platinum resistance in ovarian cancer,this article summarizes the recent literature related to circRNA and platinum resistance in ovarian cancer.
