Research progress of α-synuclein in the pathogenesis of Parkinson's disease
- VernacularTitle:α-突触核蛋白在帕金森病发病机制中的研究进展
- Author:
Ke-Ting LIU
1
;
Ze-Min HE
;
Bai-Yuan YANG
;
Cheng-Qing ZHONG
;
Wei GOU
;
Li XIAO
Author Information
- Keywords: Parkinson's disease; α-synuclein; gut-brain axis
- From: Journal of Regional Anatomy and Operative Surgery 2023;32(12):1091-1094
- CountryChina
- Language:Chinese
- Abstract: Parkinson's disease(PD)is the most common neurodegenerative disease,and Lewy bodies(LBs)is the most typical pathological change.α-synuclein(α-syn),as the main component of LBs,is considered as the pathogenic factor of PD.According to the transmission hypothesis,pathological α-syn can be transported from damaged neurons to normal neurons,leading to pathological misfolding and aggregation of α-syn in recipient neurons,resulting in cascading neuronal damage.According to the hypothesis of gut-brain axis,pathological α-syn can be produced in the intestine,and uploaded to the central nervous system via the vagus nerve.In this paper,the role of α-syn in the pathogenesis of PD is summarized,in order to provide reference for the study of intervention targets of PD.
