Research progress on distribution characteristics and pathogenesis of periapical microorganisms in chronic periapical periodontitis
10.3760/cma.j.cn341190-20230210-00088
- VernacularTitle:慢性根尖周炎根周微生物分布特征及致病机制的研究进展
- Author:
Yanren CHEN
1
;
Shuli DENG
;
Zhuo CHEN
Author Information
1. 浙江大学医学院附属口腔医院 浙江大学口腔医学院 浙江省口腔疾病临床医学研究中心 浙江省口腔生物医学研究重点实验室 浙江大学癌症研究院，杭州 310000
- Keywords:
Periapical periodontitis;
Bacteria;
Virulence;
Defense mechanisms;
Review
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(4):622-626
- CountryChina
- Language:Chinese
-
Abstract:
Periapical periodontitis arises from the interaction between microbial factors and the inflammatory response of the host's periapical tissues. In this process, bacteria and their byproducts serve as the primary drivers for the initiation, progression, and spread of the disease. Pulp infections and periapical lesions are primarily dominated by gram-negative bacteria. The endotoxin lipopolysaccharide component of these bacteria plays a crucial role in pulp infection, triggering clinical symptoms, inflammatory reactions, and bone tissue resorption. Similarly, lipoteichoic acid and lipopolysaccharide from gram-positive bacteria exhibit similar pathogenic characteristics, causing damage to pulp and periapical tissues. The aim of this review is to delve deeper into the distribution patterns and pathogenesis of periapical microorganisms in chronic periapical periodontitis.
