Efficacy of recombinant human interferon α-2b spray, administered under medication guidance, in the treatment of herpangina
10.3760/cma.j.cn341190-20230220-00119
- VernacularTitle:基于用药指导下的重组人干扰素α-2b喷雾剂治疗疱疹性咽峡炎的效果分析
- Author:
Minqing TONG
1
;
Zhigang LIN
;
Lili ZHU
;
Shunxin XU
Author Information
1. 永康市第一人民医院儿科门急诊，永康 321300
- Keywords:
Herpangina;
Chemokines;
Prognosis;
Medication adherence;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(4):505-509
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of recombinant human interferon α-2b spray, administered under medication guidance, in the clinical treatment of herpangina.Methods:A total of 76 children with herpangina who were treated at The First People's Hospital of Yongkang between October 2020 and October 2022 were included in this study. Using the random number table method, these patients were randomly assigned to an observation group ( n = 42) and a control group ( n = 34). The control group received conventional treatment, whereas the observation group was administered recombinant human interferon α-2b spray under medication guidance. A comparative analysis was conducted between the two groups, evaluating clinical efficacy, inflammatory factor levels, treatment compliance, and the negative conversion rate of throat swab virology. Results:After treatment, the overall response rate of the observation group [95.24% (40/42)] and treatment compliance [97.62% (41/42)] were significantly higher than those of the control group [76.47% (26/34), 79.41% (27/34), χ2 = 4.27, 4.82, P = 0.040, 0.030]. The levels of C-reactive protein [(6.28 ± 1.64) mg/L], white blood cell count [(6.11 ± 1.10) × 10 9], and serum amyloid A [(3.47 ± 0.89) mg/L] in the observation group were significantly lower than those in the control group [(7.51 ± 1.16) mg/L, (7.51 ± 1.16) × 10 9, (7.82 ± 1.30) mg/L, t = 3.69, 6.46, 17.27, all P < 0.001]. The positive conversion rate of throat swab virology in the observation group [4.76% (2/42)] was lower than that in the control group [26.47% (9/34), χ2 = 5.51, P = 0.190]. Conclusion:The use of recombinant human interferon α-2b spray under medication guidance in the treatment of herpangina can improve treatment compliance, rapidly alleviate clinical symptoms, and significantly improve the prognosis.
