Individualized thrombolysis-assisted comprehensive intervention for deep vein thrombosis in the lower limbs
10.3760/cma.j.cn341190-20230101-00001-1
- VernacularTitle:个体化溶栓辅助下综合介入治疗下肢深静脉血栓的临床研究
- Author:
Tianhua YUE
1
;
Peng YUAN
;
Fajing CHEN
;
Suwen SHEN
;
Jian WANG
;
Wei XING
Author Information
1. 扬州大学建湖临床医学院介入科，盐城 224700
- Keywords:
Venous thrombosis;
Lower extremity;
Balloon embolectomy;
Thrombolytic therapy;
Vena cava filters;
Fibrinogen;
Postthrombotic syndrome;
Combined modality ther
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(1):81-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy of individualized thrombolysis-assisted comprehensive intervention for deep vein thrombosis (DVT) in the lower limbs.Methods:This study included 32 patients with acute lower limb DVT diagnosed by angiography who received treatment at the Jianhu Clinical Medical College of Yangzhou University from March 2012 to November 2021. These patients first received implantation of an inferior vena cava filter. Then they were divided into a control group and an observation group based on treatment methods. The control group received thrombolytic catheterization and a routine infusion of urokinase. In the observation group, balloon dilation was performed first, and a large lumen catheter was used to draw blood clots. Subsequently, urokinase at a dose based on fibrinogen measurement was injected through a thrombolytic catheter. Swelling reduction, venous patency, and complications of the affected limbs were monitored.Results:In the control group, the difference in thigh circumference before treatment was (4.65 ± 1.06) cm, and after treatment, it was (2.76 ± 1.25) cm. In the observation group, the difference in thigh circumference before treatment was (4.73 ± 1.03) cm, and it was (1.40 ± 0.83) cm after treatment. In the control group, the difference in calf circumference before treatment was (2.24 ± 0.90) cm, and it was (1.56 ± 0.86) cm after treatment. In the observation group, the difference in calf circumference before treatment was (2.40 ± 0.83) cm, and it was (0.80 ± 0.73) cm after treatment. After treatment, the differences in thigh circumference and calf circumference between the healthy and affected sides were statistically significant ( t = 3.58, 2.67, both P < 0.05). After treatment, there was a significant difference in venous patency between the control and observation groups (34.02% [33/97] vs. 68.18% [60/88], t = 3.44, P < 0.05). After 12 months of follow-up, the Villalta scale score, which was used to evaluate post-thrombotic syndrome, was (9.23 ± 4.07) points in the control group, which was significantly different from (5.73 ± 3.39) points in the observation group ( t = 2.62, P < 0.05). Conclusion:Individualized thrombolysis-assisted comprehensive intervention is highly effective in the treatment of DVT in the lower limbs and results in few complications.
