Risk factors for the recurrence of cervical intraepithelial neoplasia after cervical conization
10.3760/cma.j.cn341190-20230615-00526
- VernacularTitle:宫颈上皮内瘤变锥切术后复发的相关危险因素分析
- Author:
Cuiyu HUANG
1
Author Information
1. 安溪县妇幼保健院妇产科，泉州 362400
- Keywords:
Cervical intraepithelial neoplasia;
Trachelectomy;
Risk factors;
Recidivism;
Circumferential electrodesiccation
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(12):1828-1832
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relevant risk factors for recurrence of cervical intraepithelial neoplasia (CIN) in patients undergoing cervical conization.Methods:The clinical data of 205 patients with high-grade CIN (CIN ≥ II) who received treatment in Anxi County Maternal and Child Health Hospital from January 2016 to December 2022 were retrospectively analyzed. All of these patients received loop electrosurgical excision procedure or cold knife conization. The relevant risk factors for CIN recurrence were analyzed using univariate and multivariate risk models.Results:Univariate analysis results showed that there were significant differences in the number of full-term births ( HR = 1.512, 95% CI: 1.191-1.920, P < 0.05), history of premature birth ( HR = 7.255, 95% CI: 2.645-19.900, P < 0.05), history of miscarriage ( HR = 2.158, 95% CI: 1.273-3.660, P < 0.05), positive surgical margins ( HR = 1.724, 95% CI: 1.092-2.720, P < 0.05), conization depth ( HR = 0.953, 95% CI: 0.918-0.989, P < 0.05), history of smoking ( HR = 2.143, 95% CI: 1.264-3.634, P < 0.05), and history of comorbidities ( HR = 3.392, 95% CI: 2.022-5.691, P < 0.05) among the 205 included patients. Cox multivariate risk model indicated that positive surgical margins ( HR = 2.144, 95% CI: 1.317-3.492, P < 0.05), history of premature birth ( HR = 4.515, 95% CI: 1.598-12.754, P < 0.05), and history of comorbidities ( HR = 3.552, 95% CI: 1.952-6.462, P < 0.05) were independent risk factors for recurrence of CIN after cervical conization. Conclusion:In patients with high-grade CIN undergoing cervical conization, positive surgical margins, history of premature birth, and history of comorbidities are associated with an increased risk of CIN recurrence, while a conization depth of > 0.5 cm is associated with a low risk of CIN recurrence.
