Correlation between peripheral blood neutrophil-to-lymphocyte ratio and restless legs syndrome in patients undergoing hemodialysis
10.3760/cma.j.cn341190-20220911-00709
- VernacularTitle:血液透析患者外周血中性粒细胞/淋巴细胞比值与不宁腿综合征的相关性研究
- Author:
Xiaocong LIU
1
;
Huali LYU
;
Sinan SHAO
;
Lijuan WEI
;
Xiaoqing WANG
Author Information
1. 厦门大学附属第一医院 福建医科大学第三临床医学院肾内科，厦门 361003
- Keywords:
Hemodialysis;
Restless legs syndrome;
Neutrophil-to-lymphocyte ratio;
Parathyroid hormone;
Uric acid;
Neutrophils;
Logistic models;
Factor analysis, statisti
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(11):1657-1661
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To correlate peripheral blood neutrophil-to-lymphocyte ratio with the occurrence of restless legs syndrome (RLS) in patients undergoing maintenance hemodialysis (MHD).Methods:This is a cross-sectional study. A total of 203 patients who underwent long-term MHD at the Blood Purification Center, Department of Nephrology, The First Affiliated Hospital of Xiamen University from May to June 2021 were included in this study. The counts of peripheral blood neutrophils and lymphocytes were determined and the neutrophil-to-lymphocyte ratio was calculated. These patients were divided into a RLS group and a non-RLS group according to whether they developed RLS. RLS-related factors were evaluated using face-to-face interview questionnaires. Various clinical and laboratory parameters were analyzed. The influential factors of RLS in patients undergoing MHD were analyzed through univariate regression analysis and multivariate logistic regression analysis.Results:A total of 203 patients undergoing MHD were enrolled, 30 individuals were determined as current RLS cases (14.78%). The levels of NLR and PTH in the RLS group were 4.86 (3.39, 5.82) L/L and 244.50 (143.25, 406.50) ng/L, respectively, which were significantly higher than those in the normal group [3.51 (2.60, 5.24) L/L, 147.00 (94.80, 263.50) ng/L, Z = -3.38, -2.64, both P < 0.05]. Univariate logistic regression analysis showed that NLR, PTH, uric acid, and neutrophil count were correlated with RLS (Wald χ2 = 7.96, 4.99, 4.76, 8.33, all P < 0.05). NLR was the independent risk factor of RLS (Wald χ2 = 6.14, P < 0.05) in multivariate models adjusting for confounding factor. Conclusion:The prevalence of RLS is high in patients undergoing MHD. RLS is assicuated with NLR among patients undergoing MHD after adjusting for confounding factor. RLS is likely associated with systemic inflammatory diseases.
