Therapeutic effects of Danggui Zicao ointment on diabetic pruritus caused by heat and wind in blood
10.3760/cma.j.cn341190-20220924-00741
- VernacularTitle:当归紫草膏外用治疗血热生风型糖尿病皮肤瘙痒症的疗效观察
- Author:
Shan HUANG
1
;
Lilan SHENG
;
Hongbo ZHANG
;
Jingwen LOU
Author Information
1. 金华市中医医院内分泌科，金华 321017
- Keywords:
Diabetes mellitus;
Pruritus;
Skin manifestations;
Danggui zicao ointment;
Xuereshengfeng type;
Medicine,Chinese traditional;
Comparative effectiveness Resea
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(11):1601-1604
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of Danggui Zicao ointment on diabetic pruritus caused by heat and wind in blood. Methods:A total of 197 patients with diabetic pruritus caused by heat and wind in blood who received treatment in Jinhua Hospital of Traditional Chinese Medicine from November 2020 to March 2022 were included in this randomized controlled study. They were randomly divided into a control group ( n = 99) and an observation group ( n = 98). Based on basic hypoglycemic treatment, the control group was given oral levocetirizine hydrochloride tablets, while the observation group was externally given Danggui Zicao ointment. Both groups were treated for 4 successive weeks. Pre- and post-treatment 12-Item Pruritus Severity Scale (12-PSS) score and clinical efficacy were compared between the two groups. Results:After 4 weeks of treatment, the 12-PSS score in each group significantly decreased compared with that before treatment ( t = 18.09, 11.31, both P < 0.05). The 12-PSS score in the observation group was (7.72 ± 1.64) points, which was significantly lower than (9.35 ± 2.18) points in the control group ( t = 3.52, P < 0.05). The total effective rate in the observation group was 87.8% (86/98), which was significantly higher than 76.8% (76/98) in the control group ( χ2 = 4.06, P < 0.05). Conclusion:Danggui Zicao ointment can effectively improve the clinical symptoms of patients with diabetic pruritus caused by heat and wind in blood, improve quality of life, and deserves clinical promotion.
