Effects of rhubarb combined with acupuncture treatment on plasma interleukin-6 level and T and B lymphocyte subsets in patients with severe traumatic brain injury
10.3760/cma.j.cn341190-20221215-01043
- VernacularTitle:大黄联合针刺治疗对重型颅脑损伤患者血浆IL-6及T、B淋巴细胞亚群的影响
- Author:
Fengyan RONG
1
;
Yonglin WANG
;
Jinxiu LI
Author Information
1. 聊城市第二人民医院 山东第一医科大学附属聊城二院重症医学科,聊城 252600
- Keywords:
Craniocerebral injury;
Acupuncture points;
Rhubarb;
T lymphocytes;
B lymphocytes;
Interleukins;
Glasgow prognostic score;
Treatment outcome;
Prognosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(10):1477-1482
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of rhubarb combined with acupuncture treatment on plasma interleukin-6 (IL-6) and T and B lymphocyte subsets in patients with severe traumatic brain injury.Methods:A total of 112 patients with severe traumatic brain injury who received treatment in The Second People's Hospital of Liaocheng from September 2020 to August 2022 were included in this study. They were randomly divided into a control group and an observation group ( n = 56 per group). Both groups were given routine treatment. Additionally, the control group was treated with rhubarb, while the observation group was treated with rhubarb and acupuncture. The ratios of T lymphocyte subsets to B lymphocyte subsets, IL-6 levels, and prognoses were compared between the two groups. Results:After treatment, the total effective rate in the observation group was 89.29% (50/56), which was significantly higher than 73.21% (41/56) in the control group ( χ2 = 4.75, P = 0.029). At 7 days after treatment, IL-6 level in each group was significantly decreased compared with that before treatment ( P < 0.05). At 7 days after treatment, IL-6 level in the observation group was (469.60 ± 196.54) mg/L, which was significantly lower than (695.25 ± 277.67) mg/L in the control group ( t = 4.96, P < 0.05). The ratios of T lymphocyte subsets (CD 4+, CD 8+, CD 4+/CD 8+) to B lymphocyte subsets (CD 19+, CD 20+) in the observation group were significantly higher than those in the control group and were closer to the normal ratios (all P < 0.05). At 3 months after treatment, the Glasgow Outcome Scale scores in each group were significantly increased compared with those at 1 month after treatment (both P < 0.05). At 1 and 3 months after treatment, the Glasgow Outcome Scale scores in the observation group were (2.94 ± 0.53) points and (4.06 ± 0.53) points, respectively, which were significantly higher than (2.63 ± 0.58) points and (3.72 ± 0.48) points in the control group ( t = 2.95, 3.56, both P < 0.05). Conclusion:Rhubarb combined with acupuncture can greatly reduce serum IL-6 level in patients with severe traumatic brain injury, regulate the ratio of T lymphocyte subsets to B lymphocyte subsets, reduce inflammatory reactions, and improve prognosis.
