Effects of different deoxyepinephrine administration methods on hypotension in patients undergoing thoracoscopic general anesthesia
10.3760/cma.j.cn341190-20230417-00297
- VernacularTitle:去氧肾上腺素不同给药方式对胸腔镜全身麻醉手术患者低血压的影响
- Author:
Chong CHEN
1
;
Zhongquan ZHU
;
Zhen CAI
Author Information
1. 金华市中心医院麻醉科，金华 321000
- Keywords:
Thoracoscopy;
Deoxyepinephrine;
Anesthesia, general;
Injections, intravenous;
Hemodynamics;
Hypotension
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(9):1351-1355
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of different deoxyepinephrine administration methods on hypotension in patients undergoing thoracoscopic general anesthesia.Methods:A total of 120 patients undergoing thoracoscopic general anesthesia in Jinhua Municipal Central Hospital from January 2020 to January 2023 were included in this study. They were randomly divided into a control group and an observation group ( n = 60 patients per group). Patients in the control group were given deoxyepinephrine once, and patients in the observation group were continuously pumped with deoxyepinephrine. Other anesthesia methods in the two groups were the same. Hemodynamic indexes (systolic blood pressure, diastolic blood pressure, and heart rate), incidence of hypotension (during anesthesia induction and operation), anesthesia time, operation time, urine volume, blood loss, infusion volume, and dosage of deoxyepinephrine were recorded. Results:At the time at which the first systolic blood pressure decreased by > 20% of the baseline (T1) and 5 minutes after T1 (T2), the systolic blood pressures in the observation group were significantly higher than those in the control group [T1: (99.77 ± 11.42) mmHg vs. (95.34 ± 15.37) mmHg, t = 1.79, P = 0.038; T2: (120.49 ± 12.48) mmHg vs. (113.45 ± 16.03) mmHg, t = 2.68, P = 0.004; 1 mmHg = 0.133 kPa]. At T1 and T2, diastolic blood pressures in the observation group were significantly higher than those in the control group [T1: (62.60 ± 5.81) mmHg vs. (59.43 ± 6.35) mmHg, t = 2.85, P = 0.003; T2: (73.61 ± 7.01) mmHg vs. (70.20 ± 8.15) mmHg, t = 2.46, P = 0.008]. The incidences of hypotension during anesthesia induction and surgery in the observation group were 8.33% (5/60) and 15.00% (9/60), respectively, which were significantly lower than 26.67% (16/60) and 33.33% (20/60) in the control group ( χ2 = 6.98, P = 0.008; χ2 = 5.50, P = 0.019). There were no significant differences in anesthesia time ( t = 0.19, P = 0.425) and operative time ( t = 0.27, P = 0.396) between the two groups. There were no significant differences in urine volume ( t = 0.92, P = 0.179), blood loss ( t = 1.02, P = 0.155), and infusion volume ( t = 0.91, P = 0.182) between the two groups. There was no significant difference in the dosage of deoxyepinephrine between the two groups ( t = 1.11, P = 0.134). Conclusion:Continuous infusion of deoxyepinephrine in patients undergoing thoracoscopic general anesthesia yields superior efficacy than a single administration of deoxyepinephrine. The former can stabilize the hemodynamic indicators of patients during surgery and reduce the incidence of hypotension.
