Serum leptin, adiponectin and endometrial cancer risk in Chinese women.
10.3802/jgo.2013.24.4.336
- Author:
Yu MA
1
;
Zhiwei LIU
;
Yan ZHANG
;
Bingjian LU
Author Information
1. Department of Clinical Laboratory, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
- Publication Type:Original Article
- Keywords:
Adiponectin;
Endometrial carcinoma;
Insulin resistance;
Leptin
- MeSH:
Adiponectin;
Asian Continental Ancestry Group;
Body Mass Index;
Case-Control Studies;
Cholesterol;
Endometrial Neoplasms;
Fasting;
Female;
Glucose;
Humans;
Insulin;
Insulin Resistance;
Leptin;
Lipoproteins;
Logistic Models;
Triglycerides
- From:Journal of Gynecologic Oncology
2013;24(4):336-341
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate the relationship between serum concentrations of leptin or adiponectin, and endometrial carcinoma in Chinese women. METHODS: We conducted a case-control study of a total of 516 Chinese women to detect the relationships between serum concentrations of leptin or adiponectin, and endometrial carcinoma in Chinese women. The study subject constituted 206 cases of endometrial cancer and 310 normal controls. RESULTS: Patients with endometrial carcinoma had higher serum leptin concentrations than controls (28.8+/-2.2 ug/L vs. 19.8+/-1.4 ug/L; p<0.001). The adiponectin levels in patients were lower than in controls with borderline statistical significance (2,330.7+/-180.5 ug/L vs. 2,583.9+/-147.2 ug/L; p=0.078). Logistic regression analysis confirmed the associations between leptin or adiponectin, and endometrial carcinoma after adjustment for age, body mass index, fasting insulin, serum glucose, cholesterol, triglycerides, and high-density lipoprotein cholesterol (odds ratio for the top tertile vs. the bottom tertile: leptin 2.05; 95% confidence interval [CI], 1.28 to 3.29; p<0.001; adiponectin 0.52; 95% CI, 0.32 to 0.83; p<0.001). CONCLUSION: Increased leptin or decreased adiponectin levels are associated with endometrial carcinoma.
