Antimicrobial resistance of Pseudomonas aeruginosa:surveillance report from Hunan Provincial Antimicrobial Resistance Surveillance System,2012-2021
10.12138/j.issn.1671-9638.20233827
- VernacularTitle:湖南省细菌耐药监测网2012-2021年铜绿假单胞菌耐药性监测报告
- Author:
Jian-Long LIU
1
;
Chun-Rong SONG
;
Min FU
;
Qiong HU
;
Li-Hua CHEN
;
Chen-Chao FU
;
Chen LI
;
Yan-Ming LI
;
Jun LIU
;
Xing-Wang NING
;
Guo-Min SHI
;
Jing-Min WU
;
Huai-De YANG
;
Hong-Xia YUAN
;
Ming ZHENG
;
Xun HUANG
;
An-Hua WU
;
Nan REN
Author Information
1. 湖南省儿童医院检验中心,湖南长沙 410007
- Keywords:
bacteria;
antimicrobial agent;
Pseudomonas aeruginosa;
antimicrobial resistance;
surveillance;
Hu-nan Provincial Antimicrobial Resistance Surveillance System
- From:
Chinese Journal of Infection Control
2023;22(12):1452-1459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the distribution and changes in antimicrobial resistance of clinically isolated Pseudomonas aeruginosa(P.aeruginosa)in the member hospitals of Hunan Provincial Antimicrobial Resistance Surveillance System from 2012 to 2021.Methods Antimicrobial susceptibility testing by disk diffusion or automa-ted instrument was performed on clinical isolates.Testing results were determined according to the standards of 2022 edition from American Clinical Laboratory Standards Institute(CLSI).Statistical analysis was performed by WHONET 5.6 software.Data were analyzed by trend test(Cochran-armitage)and Chi-square test with SPSS.Results A total of 176 441 strains of P.aeruginosa were surveilled by Hunan Provincial Antimicrobial Resistance Surveillance System from 2012 to 2021.99.4％of the strains were isolated from hospitalized patients,and about 70％of the strains were isolated from respiratory specimens.8.4％of P.aeruginosa were from children(0-17 years old),91.6％were from adults.Antimicrobial susceptibility testing results showed that P.aeruginosa was most sensitive to polymyxin B over 10 years,with a resis-tance rate of less than 6％.Resistance rates to piperacil-lin,piperacillin/tazobactam,ceftazidime,cefepime,aztreonam,imipenem,amikacin,gentamicin,tobramycin,cip-rofloxacin,levofloxacin,and polymyxin B all showed downward trends.A total of 29 920 carbapenem-resistant P.aeruginosa(CRPA)strains were detected.The average isolation rate of CRPA in this province was 18.0％over 10 years.CRPA detection rate from adult was 18.5％,higher than that from children(12.3％),and both showing downward trends.Conclusion The resistance rate of clinically isolated P.aeruginosa in Hunan Province to most commonly used antimicrobial agents is decreasing.
