Chinese expert consensus on diagnosis and treatment strategies for SARS-CoV-2 infection in immunocompromised populations(2023 edition-2)
10.12138/j.issn.1671-9638.20234364
- VernacularTitle:免疫缺陷人群新型冠状病毒感染诊治策略中国专家共识(2023.V2版)
- Author:
Chun-Rong JU
1
,
2
,
3
,
4
;
Mei-Ying WANG
;
Jing YUAN
;
Yong-Hao XU
;
Zhi-Bin XU
;
Pei-Hang XU
;
Yu-Peng LAI
;
Li-Yan CHEN
;
Shi-Yue LI
;
Wu-Jun XUE
;
Hong-Zhou LU
;
Yi-Min LI
;
Yun-Song YU
Author Information
1. 广州医科大学附属第一医院广州呼吸健康研究院,广东广州 510120
2. 国家呼吸医学中心,广东广州 510120
3. 国家呼吸疾病临床研究中心,广东 广州 510120
4. 呼吸疾病国家重点实验室,广东 广州 510120
- Keywords:
SARS-CoV-2;
immunocompromised population;
pneumonia;
small molecule drug
- From:
Chinese Journal of Infection Control
2023;22(12):1411-1424
- CountryChina
- Language:Chinese
-
Abstract:
Since the end of 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has swept the world,bringing great harm to human society and significantly increasing the health burden.Due to stron-ger infectivity,faster transmission,and higher reinfection rate of the Omicron variant,it has now replaced the Delta variant as the main epidemic strain for both imported and local outbreaks in China.Chinese Diagnosis and treatment protocol for SARS-CoV-2 infection(10th trial version)emphasizes"strengthening the protection of key popula-tions,"which includes the increasing number of immunocompromised population.These people have a high inci-dence of severe diseases and a high fatality rate after infected with SARS-CoV-2,and belong to the high-risk popula-tions of severe or critical diseases.Moreover,due to underlying diseases,these people take immunosuppressants and other related drugs chronically.The interactions between anti-SARS-CoV-2 infection treatment drugs and origi-nal drugs are complicated,thus bring significant challenges to the treatment after the SARS-CoV-2 infection.Cur-rently,there is a lack of guidelines or consensus on the diagnosis and treatment of SARS-CoV-2 infection among im-munocompromised population.Therefore,the Guangzhou Institute of Respiratory Health and National Center for Respiratory Medicine organized experts from multiple disciplines(respiratory and critical care medicine,organ transplantation,rheumatology and immunology,hematology,infection,critical care medicine,etc.)in China.Af-ter multiple rounds of discussions,13 items of recommendations are made as the reference for peers based on evi-dence-based medical evidence,so as to provide a theoretical and practical reference for the diagnosis and treatment strategies of this population.
