Simultaneous detection of 34 emerging contaminants in tap water by HPLC-MS/MS and health risk assessment
10.13618/j.issn.1001-5728.2024.01.005
- VernacularTitle:HPLC-MS/MS法检测自来水中34种新污染物及健康风险评估
- Author:
Yixuan CAO
1
,
2
,
3
;
Ziwei YUAN
;
Xiaoxi MU
;
Chenshan LV
;
Haiyan CUI
;
Tao WANG
;
Zhiwen WEI
;
Zhongbing CHEN
;
Hongyan ZOU
;
Keming YUN
;
Meng HU
Author Information
1. 山西医科大学法医学院,山西晋中 030600
2. 山西法医学重点实验室,山西晋中 030600
3. 法庭毒物分析公安部重点实验室,山西晋中 030600
- Keywords:
Environmental forensics;
Tap water;
Emerging contaminants;
Solid phase extraction;
HPLC-MS/MS;
Health Risk
- From:
Chinese Journal of Forensic Medicine
2024;39(1):31-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a simultaneous detection approach for 34 emerging contaminants(ECs)in tap water by liquid chromatography-tandem mass spectrometry(HPLC-MS/MS).Human health risk assessment was performed according to the detection results from 43 tap water samples.Methods Tap water samples were concentrated and extracted by solid phase extraction,and then blown to near dry by nitrogen at 40℃.The sample extracts were dissolved in methanol-water solution(95:5,VN)to 0.5 mL for analyzing.Agilent Jet Stream Electrospray Ionization(AJS ESI)and the multiple reaction monitoring(MRM)mode were performed for MS to acquire the data of 34 ECs.A database including precursor ion,product ion and retention times was established accordingly.Results The average linear correlation coefficients(r)of 34 kinds of ECs was 0.995 9.The limits of detection were 0.01～0.60 ng/L and the recoveries were between 60.7％and 119.8％.The intra-group precisions were between 0.05％～9.89％and the intra-day precisions were between 0.20％～14.40％for the spiked samples.The method was applied to analyze 43 tap water samples and a total of 15 ECs were detected.According to the results,the detection rate of caffeine was the highest(84％),and the concentration range was ND～74.42 ng/L.Among all the ECs detected,1,2,3-benzotriazole had the highest concentration(ND～361.15 ng/L),where detection rate was 44％.Humans may be exposed to these ECs by drinking the tap water.The human health risk assessments of 12 kinds of ECs were carried out,however,the estimated risk was negligible(risk quotient＜0.01).Conclusion The method is simple,highly sensitive and selective,and could meet the detection needs of ECs at trace level in tap water.There was no human health risk posed for ECs identified in 43 tap water samples analyzed by this method.
